Hydroxycitric acid is found in a high concentration, ranging from 10% to 30% in the dried out fruit rind of Garcinia cambogia.
The dried rind has actually been utilized for centuries throughout Southeast Asia as a way of preserving foods and seasonings.
As probably already know extensive experimental research studies have revealed that Hydroxycitric acid (HCA) hinders fat synthesis and decreases food intake.
Taking a supplement that contains 50% HCA has many different health benefits that include weight loss.
*BUT too much of a good thing can also be dangerous and unhealthy.
How Hydroxycitric Acid Works
The main mechanism of action of hydroxycitric acid appears to be connected to its ability to serve as a competitive inhibitor of the enzyme ATP-citrate lyase, which catalyzes the conversion of citrate and coenzyme A to oxaloacetate and acetyl coenzyme A (acetyl-CoA), main building blocks of fatty acid and cholesterol synthesis.
It’s this action that lowers bad cholesterol while helping you lose weight.
Hydroxycitric acid from Hibiscus subdariffa prevents alpha-amylase and alpha-glucosidase, causing decrease of carbohydrate metabolic process. This is why it’s called a “Carb Blocker” and this action happens in the liver.
Depriving the body of carbs will help you lose weight but if you use higher strengths , over 61% HCA your liver could suffer from damage as there have been NO clinical testing at this high of levels.
Note: Testing has only been completed at 50% HCA levels.
Hydroxycitric Acid and Weight Reduction
The HCA element has actually been reported to burn body fat loss in humans without stimulating our very sensitive nervous system. The level of effectiveness towards the weight loss benefits of garcinia solely depends on the quality, dosage and grade of the hydroxycitric acid. Thus other additional health benefits can be increased by the same contributions.
Too Much Hydroxycitric Acid Can Cause Liver Damage
Before you read the clinical data below you must understand the recommended dosage of garcinia cambogia is 3000mg at 50% – 60% HCA.
You can take up to 4000mg but only if you are NOT seeing much in the way of results.
The weight-loss effectiveness of water-soluble, calcium-potassium salt of hydroxycitric acid was re-examined in 90 obese subjects (BMI: 30-50.8 kg/m2).
We incorporated information from 1 formerly reported randomized, double-blind, placebo-controlled scientific research studies that used 50% HCA Levels, in order to accomplish a better analytical evaluation based on a bigger populace.
Subjects were randomly divided into three groups:
Group A received an everyday dose of garcinia hydroxycitric acid 4, 667 mg (offering 2,800 mg hydroxycitric acid per day).
Group B was given an everyday dosage of a combination of hydroxycitric acid 4,667 mg, niacin-bound chromium (NBC) 4 mg (offering 400 microg elemental chromium), and Gymnema sylvestre extract (GSE) 400 mg (providing 100 mg gymnemic acid).
Group C received a placebo in three equally divided doses 30-60 minutes prior to each dish. Eighty-two targets finished the research study.
Here are the results at the end of 8 weeks.
Group A, both body weight and BMI decreased by 5 %, low-density lipoprotein and triglycerides levels were reduced by 12 % and 6 %, respectively, while high-density lipoprotein levels enhanced by 8.9 %, serum leptin levels decreased by 38 %, serotonin levels enhanced by 44 % and urinary excretion of fat metabolites enhanced by 32-109%.
Group B showed similar beneficial modifications, but generally to a greater level. There were NO Garcinia Side Effects at these levels.
Group C showed no substantial changes at all.
The incorporated outcomes confirm that hydroxycitric acid and, to a greater degree, the mix of hydroxycitric acid plus NBC and GSE reduce body weight and BMI, suppress appetite, improve blood lipid profiles, boost serum leptin and serotonin levels and enhance fat oxidation more than the placebo group C.
We conclude that 50% dosage levels, timing of administration, subject compliance and bioavailability of hydroxycitric acid significantly impact outcomes and that when taken as directed, hydroxycitric acid at 50% levels is a highly effective accessory to healthy weight control with NO SIDE EFFECTS.
So is it Safe For The Liver? YES!!!
Garcinia cambogia extract (GCE) with its active element consisting of hydroxycitric acid (50% HCA) does contain various HCA salts, including calcium, magnesium, potassium and mixtures of these that do aid in it’s effectiveness.
Experimentally, these salts show various positive effects, however not all help improve glucose tolerance and blood pressure.
Recently, obesity-prone mice were fed a high-fat diet plan (HFD, 45 kcal % fat) with or without GCE (1 %, w/w) for 16 wk. The active arm lowered visceral fat, adipocyte size and serum glucose, yet purportedly likewise shown hepatic collagen buildup, lipid peroxidation and enhanced mRNA levels of genes associated with oxidative stress.
The latter findings are at odds with a huge body of animal and human studies that have actually been conducted on the safety and efficacy of HCA.
This literature reveals HCA to be safe versus the liver toxicity related to ethanol and dexamethasone administration, and to preserve serum aspartate aminotransferase, alanine aminotransferase and alkaline phosphatase at near typical levels.
This tells us that if you take garcinia cambogia with HCA levels between 50% – 60% the liver is not effected although I would caution that not much long term testing has been conducted.